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Antigenic Specificity | COL4A3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.6 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total COL4A3 protein. Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase i |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human collagen, type IV, alpha 3 (Goodpasture antigen) |
Other Names | [CO4A3; COL4A3; Goodpasture antigen; Tumstatin] |
Gene, Accession # | [COL4A3], Gene ID: 1285, NCBI: NP_000082.2, UniProt: Q01955 |
Catalog # | MBS9402704 |
Price | $255 |
Order / More Info | COL4A3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |