Edit |   |
---|---|
Antigenic Specificity | CD11a (inhibitor) |
Clone | [NKI(SPV)-L7] |
Host Species | Mouse (Balb/c) |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The monoclonal antibody SPV-L7 reacts with the alpha chain of LFA-1, the CD11a/CD18 integrin heterodimer present on Human T- and B-lymphocytes, granulocytes and monocytes. Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a Human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 |
Immunogen | Source Note: The antibody was obtained by immunisation of Balb/c mice with cells of the T4+T8- cytotoxic T lymphocyte clone HG-38. The antibody was selected for inhibition of T-cell mediated killing by screening of the hybridoma supernatants 10-14 days after the fusion. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS570246 |
Price | $415 |
Order / More Info | CD11a (inhibitor) Antibody from MYBIOSOURCE INC. |
Product Specific References | Keizer G.D., J. Borst, C.G. Figdor, H. Spits, F. Miedema, C. Terhorst, J.E. de Vries. Eur. J. Immunol. 15: 1142-1147, 1985. |