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Antigenic Specificity | CASP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CASP3 (NP 004337.2). |
Other Names | [CPP32; SCA-1; CPP32B] |
Gene, Accession # | [CASP3], Gene ID: 836, NCBI: NP_004337.2, UniProt: P42574 |
Catalog # | MBS8543942 |
Price | $280 |
Order / More Info | CASP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |