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Antigenic Specificity | Phospho-Tuberin/TSC2 (Ser1387) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Tuberin/TSC2 (Ser1387) antibody detects endogenous levels of Tuberin/TSC2. Function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).Subunit Structure: Probably forms a complex composed of chaperones HSP90 and HSP70, co-ch |
Immunogen | Immunogen: A synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Ser1387. Subcellular Location: Cytoplasm. Membrane. At steady state found in association with membranes. Tissue Specificity: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. |
Other Names | [FLJ43106; LAM; OTTHUMP00000158940; OTTHUMP00000198394; OTTHUMP00000198395; PPP1R160; Protein phosphatase 1, regulatory subunit 160; tsc2; TSC2_HUMAN; TSC4; TSC4 gene, formerly; TSC4, formerly; Tuberin; Tuberous sclerosis 2; Tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog] |
Gene, Accession # | [TSC2], Gene ID: 7249, NCBI: NP_000539.2, UniProt: P49815 |
Catalog # | MBS9600758 |
Price | $240, $280 |
Order / More Info | Phospho-Tuberin/TSC2 (Ser1387) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |