ICAD Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | ICAD |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The inhibitor of caspase-3-activated DNase (ICAD) is a caspase-3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of M.W. 45 kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a M.W.35 kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. In |
| Immunogen | Immunogen: ICAD antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
| Other Names | [Rabbit ICAD; ICAD; ICAD; DFFA; DNA fragmentation factor; 45kDa; alpha polypeptide; BOS_15806; DFF1; DFF35; DFF45; DFF-45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor; alpha polypeptide; DNA fragmentation factor; alpha subunit; DNA fragmentation factor subunit alpha; H13; ICAD; ICAD-L; ICAD-S; inhibitor of CAD; RP23-121D17.3] |
| Gene, Accession # | [ICAD], NCBI: SMF97944.1 |
| Catalog # | MBS5310059 |
| Price | $375 |
| Order / More Info | ICAD Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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