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Antigenic Specificity | Human IDE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | DyLight 488 conjugate |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: No cross reactivity with other proteins. Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primari |
Immunogen | Immunogen: E Coli-derived human IDE recombinant protein (Position: F485-K756). |
Other Names | [Rabbit IgG Human IDE DyLight 488 Conjugated, Flow Validated; Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin; IDE; Insulin degrading enzyme] |
Gene, Accession # | [IDE], Gene ID: 3416, NCBI: NP_001159418.1, UniProt: P14735 |
Catalog # | MBS1751338 |
Price | $330 |
Order / More Info | Human IDE Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Entrez Gene: IDE insulin-degrading enzyme. 2. Affholter JA, Fried VA, Roth RA (Dec 1988). Human insulin-degrading enzyme shares structural and functional homologies with E Coli protease III. Science. 242 (4884): 1415-8. |