PKC iota Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PKC iota |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for Protein kinase C iota type(PRKCI) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Background: Protein kinase C iota type, also called PKCI, is an enzyme that in humans is encoded by the PRKCI gene. This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathwa |
| Immunogen | Immunogen: E Coli-derived human PKC iota recombinant protein (Position: D21-Q214). Human PKC iota shares 96% and 97% amino acid (aa) sequence identity with mouse and rat PKC iota, respectively. Ig Type: Rabbit IgG |
| Other Names | [Protein kinase C iota type; aPKC lambda/iota; aPKC-lambda/iota; Atypical protein kinase C lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI_HUMAN; MGC26534; nPKC iota; nPKC-iota; nPKCiota; PKC lambda; PKCI; PKCiota; PKClambda; PRKC I; PRKC iota; PRKC lambda/iota; PRKC-lambda/iota; PRKCI; Protein kinase C iota; Protein kinase C iota type; protein kinase C, iota], [PRKCI; PRKCI; PKCI; DXS1179E; nPKC-iota; DXS1179E; PRKC-lambda/iota; aPKC-lambda/iota] |
| Gene, Accession # | [PKC iota], Gene ID: 5584, NCBI: NP_002731.4, UniProt: P41743 |
| Catalog # | MBS177976 |
| Price | $315 |
| Order / More Info | PKC iota Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Atwood, S. X., Li, M., Lee, A., Tang, J. Y., Oro, A. E. GLI activation by atypical protein kinase C lambda/iota regulates the growth of basal cell carcinomas. Nature 494: 484-488, 2013. 2. De Donato, M., Gallagher Jr., D. S., Davis, S. K, Stelly, D. M., Taylor, J.F. The assignment ofPRKCI to bovine chromosome 1q34-q36 by FISH suggests a new assignment to human chromosome 3. Cytogenet. Cell Genet. 95: 79-81, 2001. 3. Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (August 1995). Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. Genomics 26(3): 629-31. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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