Desmin K5 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Desmin K5 antibody, protein, ELISA kits.
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| Antigenic Specificity | Desmin K5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | bovine, chicken, Caprine, hamster, human, mouse, rat, zebrafish |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.25 mL |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: K5 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors. Desmin is a 53 kDa intermediate filament protein and exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development and muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of desmin and vimentin has been observed in tumors derived from muscle tissue, |
| Immunogen | n/a |
| Other Names | [desmin; Desmin; desmin; OTTHUMP00000064865; intermediate filament protein; desmin], [DES; DES; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793] |
| Gene, Accession # | Gene ID: 1674, NCBI: NP_001918.3, UniProt: P17661 |
| Catalog # | MBS573010 |
| Price | $295 |
| Order / More Info | Desmin K5 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Ramaekers FC, Puts JJ, Moesker O, Kant A, Huysmans A, Haag D, Jap PH, Herman CJ, Vooijs GP (1983). Antibodies to intermediate filament proteins in the immunohistochemical identifiCation of Human tumours: an overview. Histochem J, 15, 691-713 Quax W, Van den Broek L, Egberts WV, Ramaekers F, Bloemendal H (1985). Characterization of the Hamster desmin gene: expression and formation of desmin filaments in nonmuscle cells after gene transfer. Cell, 43, 327-38. Pieper FR, Slobbe RL, Ramaekers FC, Cuypers HT, Bloemendal H (1987). Upstream regions of the Hamster desmin and vimentin genes regulate expression during in vitro myogenesis. EMBO J, 6, 3611-8. Krimpenfort PJ, Schaart G, Pieper FR, Ramaekers FC, Cuypers HT, Van den Heuvel RM, Vree Egberts WT, van Eys GJ, Berns A, Bloemendal H (1988). Tissue-specific expression of a vimentin-desmin hybrid gene in transgenic mice. EMBO J, 7, 941-7. van den Heuvel RM, van Eys GJ, Ramaekers FC, Quax WJ, Vree Egberts WT, Schaart G, Cuypers HT, Bloemendal H (1988). Intermediate filament formation after transfection with modified Hamster vimentin and desmin genes. J Cell Sci, 88, 475-82. Pieper FR, Schaart G, Krimpenfort PJ, Henderik JB, Moshage HJ, van de Kemp A, Ramaekers FC, Berns A, Bloemendal H (1989). Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells. J Cell Biol, 108, 1009-24. Schaart G, Viebahn C, Langmann W, Ramaekers F (1989). Desmin and titin expression in early postimplantation Mouse embryos. Development, 107, 585-96. Raats JM, Pieper FR, Vree Egberts WT, Verrijp KN, Ramaekers FC, Bloemendal H (1990). Assembly of amino-terminally deleted desmin in vimentin-free cells. J Cell Biol, 111, 1971-85. Council, L., Hameed, O. (2009). Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma Modern Pathology 22, 639-50. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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