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Antigenic Specificity | FZD7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differen |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human FZD7 (NP 003498.1). |
Other Names | [FzE3] |
Gene, Accession # | [FZD7], Gene ID: 8324, NCBI: O75084.2, UniProt: O75084 |
Catalog # | MBS8545348 |
Price | $280 |
Order / More Info | FZD7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |