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Antigenic Specificity | MKNK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MKNK1 antibody detects endogenous levels of total MKNK1. Description: Mnk1 a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described.Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.Subunit Structure: Interacts with the C-termi |
Immunogen | Immunogen: A synthesized peptide derived from human MKNK1 Subcellular Location: Cytoplasm and Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. |
Other Names | [MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal integrating kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal integrating kinase 1; MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1; mknk1; MKNK1_HUMAN; MNK 1; Mnk1] |
Gene, Accession # | [MKNK1], Gene ID: 8569, NCBI: NP_001129025.1, UniProt: Q9BUB5 |
Catalog # | MBS9600304 |
Price | $240, $280 |
Order / More Info | MKNK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |