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Antigenic Specificity | ZBP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/thr |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 18 amino acid peptide from near the carboxy terminus of human ZBP1. |
Other Names | [Z-DNA binding protein 1, DLM-1, DAI] |
Gene, Accession # | [ZBP1], Gene ID: 81030, NCBI: EAW75510 |
Catalog # | MBS9408450 |
Price | $320 |
Order / More Info | ZBP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |