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Antigenic Specificity | HPV-18 (Human Papilloma Virus 18) |
Clone | [HPV18/1297] |
Host Species | Mouse |
Reactive Species | Type 18 of human Papilloma Virus (HPV-18) |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detec |
Immunogen | Immunogen: HPV18 E6-β-galactosidase fusion protein |
Other Names | [E6; Human Papilloma Virus; HPV type 18 E6; Protein E6] |
Gene, Accession # | [HPV-18] |
Catalog # | MBS4381462 |
Price | $190, $340, $340 |
Order / More Info | HPV-18 (Human Papilloma Virus 18) Antibody from MYBIOSOURCE INC. |
Product Specific References | Reich, N.C., et al. 1983. Mol. Cell. Biol. 3: 2143-2150. |