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Antigenic Specificity | SIN3A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SIN3A (NP 056292.1). |
Other Names | [WITKOS] |
Gene, Accession # | [SIN3A], Gene ID: 25942, NCBI: NP_001138829.1, UniProt: Q96ST3 |
Catalog # | MBS8549262 |
Price | $280 |
Order / More Info | SIN3A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |