Raf1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Raf1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Raf-1 (phospho-Ser259) antibody detects endogenous levels of Raf-1 only when phosphorylated at serine 259. This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differ |
| Immunogen | Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Raf-1 around the phosphorylation site of serine 259 (S-T-SP-T-P). |
| Other Names | [RAF1, partial; RAF proto-oncogene serine/threonine-protein kinase; RAF proto-oncogene serine/threonine-protein kinase; C-Raf proto-oncogene, serine/threonine kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1; Raf-1 proto-oncogene, serine/threonine kinase; Proto-oncogene c-RAF; cRaf; Raf-1], [RAF1; RAF1; NS5; CRAF; Raf-1; c-Raf; CMD1NN] |
| Gene, Accession # | [Raf1], Gene ID: 5894, NCBI: AAA60247.1 |
| Catalog # | MBS417734 |
| Price | $325 |
| Order / More Info | Raf1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Dougherty M K, et al. (2005) Mol Cell. 17(2): 215-224.Hekman M, et al. (2005) FEBS Lett. 579(2): 464-468.Avruch J,et al. (1994) Trends Biochem. Sci. 19, 279-283.Chong H, et al. (2001) EMBO J. 20, 3716-3727.King A J, et al. (1998) Nature. 396:180-183. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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