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Antigenic Specificity | MAPKAP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MAPKAP1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide from near the amino terminus of human MAPKAP1. |
Other Names | [Mitogen activated protein kinase associated protein 1, Sin1, stress-activated protein kinase-interacting protein 1, MIP1] |
Gene, Accession # | [MAPKAP1], Gene ID: 79109, NCBI: NP_001006618 |
Catalog # | MBS9405790 |
Price | $320 |
Order / More Info | MAPKAP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |