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Antigenic Specificity | NALP12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-κB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes. |
Immunogen | Immunogen: NALP12 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP12. Buffer: NALP12 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [NALP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3; RNO; NACHT; LRR and PYD domains-containing protein 12; Monarch-1; NLR family, pyrin domain containing 12], [NLRP12; NLRP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3; NALP12; PYPAF7; RNO] |
Gene, Accession # | [NLRP12], Gene ID: 91662, NCBI: NP_653288, UniProt: P59046 |
Catalog # | MBS151244 |
Price | $375 |
Order / More Info | NALP12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |