Apolipoprotein A1, APOA1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Apolipoprotein A1, APOA1 |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Apolipoprotein A-I (APOA1) is the major protein component of high density lipoprotein (HDL) in plasma. [1] Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. [2]It was composed of an N-terminal 4-helix bundle with a hydrophobic core and 2 C-terminal helices. [3] It has an approximate molecular weight of 28 KDa. A G/A polymorphism in the promoter of the ApoA-I gene has been associated with the age at which patients presented with Alzheimer disease. [4] Protection from Alzheimer disease by ApoA1 may rely on a synergistic interaction with alpha-tocopherol. [5] |
| Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the region of human APOA1. |
| Other Names | n/a |
| Gene, Accession # | [APOA1], NCBI: CAA00975.1 |
| Catalog # | MBS355173 |
| Price | $275 |
| Order / More Info | Apolipoprotein A1, APOA1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Breslow, J. L., Ross, D., McPherson, J., Williams, H., Kurnit, D., Nussbaum, A. L., Karathanasis, S. K., Zannis, V. I. Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc. Nat. Acad. Sci. 79: 6861-6865, 1982. 2. Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ (january 2008). Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nature Reviews Drug Discovery 7 (1): 84-99. 3. Ajees, A. A., Anantharamaiah, G. M., Mishra, V. K., Hussain, M. M., Murthy, H. M. K. Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases. Proc. Nat. Acad. Sci. 103: 2126-2131, 2006. 4. Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IG, Jessen F, Schulz A, Maier W, Kolsch H (2005). APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Ann. Neurol. 58 (3): 436-41. 5. Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS (2004). Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J. Neurochem. 91 (6): 1312-21. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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