TTBK1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-TTBK1 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | TTBK1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are know |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1. |
| Other Names | [Tau tubulin kinase 1, brain derived tau kinase, BDTK] |
| Gene, Accession # | [TTBK1], Gene ID: 84630, NCBI: NP_115927.1, UniProt: Q5TCY1 |
| Catalog # | MBS9402250 |
| Price | $320 |
| Order / More Info | TTBK1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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