Edit |   |
Antigenic Specificity | Phospho-DR6 (Thr460) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, ratpredicted: porcine, zebrafish, bovine, horse, sheep, rabbit, chicken, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-DR6 (Thr460) Antibody detects endogenous levels of DR6 only when phosphorylated at Thr460. Description: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degener |
Immunogen | Immunogen: A synthesized peptide derived from human DR6 around the phosphorylation site of Thr460. Tissue Specificity: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found |
Other Names | [TNFRSF 21; BM 018; BM018; CD358; Death receptor 6; DR 6; DR6; MGC31965; OTTHUMP00000039915; TNFR related death receptor 6; TNFRSF21; TNFRSF21 protein; TNR21_HUMAN; Tumor necrosis factor receptor superfamily member 21; Tumor necrosis factor receptor superfamily member 21 precursor] |
Gene, Accession # | [DR6], Gene ID: 27242, NCBI: O75509.1, UniProt: O75509 |
Catalog # | MBS9610514 |
Price | $225, $280, $340 |
Order / More Info | Phospho-DR6 (Thr460) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |