TrkB Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | TrkB |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | mouse, rat. predicted to work with: human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for BDNF/NT-3 growth factors receptor(NTRK2) detection. Tested with WB in Human;Mouse;Rat. Background: TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several neurotrophins, which are small protein growth factors that induce the sur |
| Immunogen | Immunogen: E Coli-derived human TrkB recombinant protein (Position: E66-E242). Human TrkB shares 91.5% and 89.8% amino acid (aa) sequence identity with mouse and rat TrkB, respectively. Ig Type: Rabbit IgG |
| Other Names | [BDNF/NT-3 growth factors receptor; AI848316; BDNF tropomyosine receptor kinase B; BDNF/NT 3 growth factors receptor; BDNF/NT-3 growth factors receptor; Brain derived neurotrophic factor receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; Neurotrophic tyrosine kinase receptor type 2; Neurotrophin receptor tyrosine kinase type 2; NTRK 2; NTRK2; NTRK2_HUMAN; Obesity, hyperphagia, and developmental delay, included; RATTRKB1; Tkrb; Trk B; Trk-B; TRKB; TrkB tyrosine kinase; TRKB1; Tropomyosin related kinase B; tyrosine kinase receptor B; Tyrosine receptor kinase B; neurotrophic tyrosine kinase, receptor, type 2], [NTRK2; NTRK2; TRKB; trk-B; GP145-TrkB; TRKB; Trk-B] |
| Gene, Accession # | [TrkB], Gene ID: 4915, NCBI: NP_001007098.1, UniProt: Q16620 |
| Catalog # | MBS177981 |
| Price | $280 |
| Order / More Info | TrkB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y. L., Harkany, T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 2. Luberg, K., Wong, J., Weickert, C. S., Timmusk, T. Human TrkB gene: novel alterative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. J. Neurochem. 113: 952-964, 2010. 3. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M., Barde, Y.-A. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467: 59-63, 2010. |
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