Phospho-RB-S795 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-RB-S795 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The retinoblastoma tumor suppressor protein, Rb, regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation (6). Specificity of different CDK/cyclin complexes has been observed in vitro (6 |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S795 of human RB Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [RB1; RB; pRb; OSRC; pp110; p105-Rb] |
| Gene, Accession # | [RB-S795], Gene ID: 5925, NCBI: NP_000312.2, UniProt: P06400 |
| Catalog # | MBS8527455 |
| Price | $310 |
| Order / More Info | Phospho-RB-S795 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Sherr, C.J. (1996) Science 274, 1672-7. 2. Nevins, J.R. (1992) Science 258, 424-9. 3. Welch, P.J. and Wang, J.Y. (1993) Cell 75, 779-90. 4. Hu, Q.J. et al. (1990) EMBO J 9, 1147-55. 5. Knudsen, E.S. and Wang, J.Y. (1997) Mol Cell Biol 17, 5771-83. 6. Lundberg, A.S. and Weinberg, R.A. (1998) Mol Cell Biol 18, 753-61. 7. Connell-Crowley, L. et al. (1997) Mol Biol Cell 8, 287-301. 8. Kitagawa, M. et al. (1996) EMBO J 15, 7060-9. 9. Geng, Y. et al. (2001) Proc Natl Acad Sci USA 98, 194-9. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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