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Antigenic Specificity | ANKRD27 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.5mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total ANKRD27 protein. May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Ra |
Immunogen | Immunogen: Fusion protein of human ANKRD27 Immunogen Type: Protein |
Other Names | [VARP; PP12899] |
Gene, Accession # | [ANKRD27], Gene ID: 84079, NCBI: NP_115515.2, UniProt: Q96NW4 |
Catalog # | MBS9417316 |
Price | $255 |
Order / More Info | ANKRD27 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |