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Antigenic Specificity | TNF-RII, Human |
Clone | 80M2 |
Host Species | Mouse |
Reactive Species | reactivity: human. cross reactivity: rat |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), FS, Immunoassay (IA), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 80M2 recognizes the extracellular part of- membrane-bound TNF-RII as well as- the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist.- TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, wher |
Immunogen | n/a |
Other Names | [Tumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor], [TNFRSF1B; TNF-RII/TNFRSF1B; TNF-RII/TNFRSF1B] |
Gene, Accession # | [TNF-RII], Gene ID: 338033, NCBI: ADU17359.1 |
Catalog # | MBS584282 |
Price | $610 |
Order / More Info | TNF-RII, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Grell, M et al; The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 1995, 83: 793 2. Till, A et al; The Met 196 - Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha induced apoptosis by impaired NF-kB signalling and target gene expression. J Biol Chem 2005, 280: 5994 3. Scherubl C. et al; Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2. Journal of Inflammation 2005, 2: 7 4. Krippner, A et al; Single chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 2008, 180: 8176 5. Fairfax, B et al; A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance. J. Immonol 2011, 186: 3058 |