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Antigenic Specificity | GRB10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GRB10 antibody detects endogenous levels of total GRB10. Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased |
Immunogen | Immunogen: A synthesized peptide derived from human GRB10 Subcellular Location: Cytoplasm. When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment. Tissue Specificity: Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. |
Other Names | [grb 10; GRB IR; grb-10; GRB10 adapter protein; GRB10 adaptor protein; GRB10; GRB10_HUMAN; GRBIR; Growth factor receptor bound protein 10; Growth factor receptor-bound protein 10; Insulin receptor binding protein; Insulin receptor binding protein GRB IR; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; Maternally expressed gene 1; MEG1; RSS] |
Gene, Accession # | [GRB10], Gene ID: 2887, NCBI: NP_001001549.1, UniProt: Q13322 |
Catalog # | MBS9602123 |
Price | $240, $280 |
Order / More Info | GRB10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |