HLA-DRB (MHC II) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | HLA-DRB (MHC II) |
| Clone | [L243] |
| Host Species | Mouse |
| Reactive Species | human, baboon, chimpanzee, monkey, squirrel, dog |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This MAb reacts with the HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR, which depends on the correct folding of the alpha/beta heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional AP's. In conjunction with the CD3/TCR comp |
| Immunogen | Immunogen: Activated human peripheral blood mononuclear cells |
| Other Names | [DRB1; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DRB1; human leucocyte antigen DRB1; Leucocyte antigen DR beta 1 chain; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein], [HLA-DRB1; HLA-DRB1; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; HLA-DRB2] |
| Gene, Accession # | [HLA-DRB1], Gene ID: 3123, NCBI: NP_002115.2, UniProt: P01911 |
| Catalog # | MBS438646 |
| Price | $190, $340, $340 |
| Order / More Info | HLA-DRB (MHC II) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Horejsi, V., et al. 1986. Characterization of seven new monoclonal antibodies against human DR, DR DP and DQ1 DQ3 antigens. Tissue Antigens 28: 288-297. Brodsky FM. A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics. 1984;19(3):179-94 Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc Natl Acad Sci U S A. 1981;78(3):1791-5 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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