SHANK1/SHANK3 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | SHANK1/SHANK3 |
| Clone | [S367-51] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2a |
| Format | APC-Cy7 conjugate |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~190 kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2. SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. |
| Immunogen | Immunogen: Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2. |
| Other Names | [Mouse Rat SHANK1/SHANK3 IgG2a; SHANK1/SHANK3 : APC/Cy7; Shank postsynaptic density protein; SH3 and multiple ankyrin repeat domains 3; Proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; ProSAP2; PSAP2;; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3,Shank3b; SPANK 2; SPANK2; KAP/SAPAP interacting protein; OTTHUMP00000174437; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Shank1a; Somatostatin receptor interacting protein; Somatostatin receptor-interacting protein; SPANK 1; SPANK1; SSTR interacting protein; SSTR-interacting protein; SSTRIP; Synamon; AI841104; DEL22q13.3; KIAA1650] |
| Gene, Accession # | [SHANK1/SHANK3], Gene ID: 59312, NCBI: NP_067708.1, UniProt: Q9JLU4 |
| Catalog # | MBS8003442 |
| Price | $510 |
| Order / More Info | SHANK1/SHANK3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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