CD80 [IDEC-114 (Galiximab)] Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD80 [IDEC-114 (Galiximab)] |
| Clone | [IDEC-114] |
| Host Species | Human |
| Reactive Species | human |
| Isotype | IgG1, lambda |
| Format | Protein A purified |
| Size | 0.2 mg |
| Concentration | 1 mg/ml |
| Applications | Block (BL), Modulate, Flow Cytometry (FC/FACS), Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas. Recombinant monoclonal antibody to CD80. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody IDEC-114 (Galiximab). Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 |
| Immunogen | Immunogen: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013) |
| Other Names | [B7-1; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7], [CD80; CD80; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1; CD28LG; CD28LG1; LAB7; B7] |
| Gene, Accession # | [CD80], Gene ID: 941, NCBI: NP_005182.1, UniProt: P33681 |
| Catalog # | MBS488347 |
| Price | $425 |
| Order / More Info | CD80 [IDEC-114 (Galiximab)] Antibody from MYBIOSOURCE INC. |
| Product Specific References | Vinjamaram et al. The use of galiximab in non-Hodgkin lymphoma. Clin Lymphoma Myeloma. 2008 Oct; 8(5):277-82 PMID:18854281 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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