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Antigenic Specificity | ISG15 (N-term) |
Clone | [1031CT2.8.3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ISG15 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-165 amino acids from the N-terminal region of human ISG15. Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in ant |
Immunogen | n/a |
Other Names | [Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRP; ISG15; G1P2; UCRP] |
Gene, Accession # | [ISG15], Gene ID: 9636, NCBI: NP_005092.1, UniProt: P05161 |
Catalog # | MBS9217047 |
Price | $165, $370 |
Order / More Info | ISG15 (N-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Blomstrom D.C.,et al.J. Biol. Chem. 261:8811-8816 (1986). Reich N.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6394-6398 (1987). Knight E. Jr.,et al.J. Biol. Chem. 263:4520-4522 (1988). Knight E. Jr.,et al.J. Biol. Chem. 263:10040-10040 (1988). Kamitani T.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. |