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Antigenic Specificity | PD-1/CD279 |
Clone | [NAT-105] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 5 Control Slides, 3 ml (Prediluted), 0.1 mL (Concentrate) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Programmed Death 1 (PD-1 or CD279) is a Type I membrane protein comprised of 268 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T-cell regulators. PD-1 is expressed on the surface of activated T-cells, B-cells, and macrophages. In comparison to CTLA-4, PD-1 more broadly negatively regulates immune responses. New data suggests that expression of PD-L1 on tumor cells inhibits anti-tumor activity through engagement f PD-1 on effector T-cells. Expression of PD-L1 on tumors is correlated with reduced survival in esophageal, pancreatic and other types of cancers, highlighting the relevance of exploring the PD-1 pathway as a target for immunotherapy. Studies have found that PD-1 is expressed on most T-cells and a small subset |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | [PD-1] |
Catalog # | MBS370123 |
Price | $130, $180, $195 |
Order / More Info | PD-1/CD279 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |