BRCC36 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | BRCC36 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BRCC36 Antibody: Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of |
| Immunogen | Immunogen: BRCC36 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC36. Buffer: BRCC36 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [BRCC36; C6.1A; BRCC36; CXorf53; C6.1A; Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex, subunit 3], [BRCC3; BRCC3; C6.1A; BRCC36; CXorf53; BRCC36; C6.1A; CXorf53] |
| Gene, Accession # | [BRCC3], Gene ID: 79184, NCBI: NP_077308, UniProt: P46736 |
| Catalog # | MBS150381 |
| Price | $375 |
| Order / More Info | BRCC36 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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