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Antigenic Specificity | GZMA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total GZMA polyclonal antibody. Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity.Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
Immunogen | Immunogen: Recombinant Human Granzyme A protein (29-262aa) |
Other Names | [CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF; GZMA; CTLA3; HFSP] |
Gene, Accession # | [GZMA], Gene ID: 3001, NCBI: NP_006135.1, UniProt: P12544 |
Catalog # | MBS9415795 |
Price | $320 |
Order / More Info | GZMA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |