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Antigenic Specificity | ST5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ST5 antibody detects endogenous levels of total ST5. Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.Subunit Structure: Isoform 1 interacts with the SH3 domain of ABL1. |
Immunogen | Immunogen: A synthesized peptide Tissue Specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). Predicted Cross Reactivity: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Bovine (90%), Horse (100%), Sheep (90%), R |
Other Names | [DENND2B; DENN domain containing protein 2B; DENN domain-containing protein 2B; DENN/MADD domain containing 2B; HeLa tumor suppression 1; HTS1; p126; ST 5; ST5; ST5_HUMAN; Suppression of tumorigenicity 5; Suppression of tumorigenicity 5 protein] |
Gene, Accession # | [ST5], Gene ID: 6764, NCBI: NP_005409.3, UniProt: P78524 |
Catalog # | MBS9604688 |
Price | $240, $280 |
Order / More Info | ST5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |