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Antigenic Specificity | ALS2CL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.3mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total ALS2CL protein. Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton |
Immunogen | Immunogen: Synthetic peptide of human ALS2CL Immunogen Type: Peptide |
Other Names | [RN49018] |
Gene, Accession # | [ALS2CL], Gene ID: 259173, NCBI: NP_001177636.1, UniProt: Q60I27 |
Catalog # | MBS9417116 |
Price | $255 |
Order / More Info | ALS2CL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |