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Antigenic Specificity | JAD1B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: JAD1B antibody detects endogenous levels of total JAD1B. Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).Subu |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken Similarity: Pig (92%), Bovine (92%), Horse (100%), Sheep (92%), Rabbit (100%), Dog (100%), Chicken (83%) |
Other Names | [Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; JARID1B; Jumonji AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; Kdm5b; KDM5B_HUMAN; Lysine (K) specific demethylase 5B; Lysine demethylase 5B; Lysine specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; PLU1; PPP1R98; Protein phosphatase 1 regulatory subunit 98; PUT1; putative DNA/chromatin binding motif; RBBP2H1A; RBP2 like; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; Retinoblastoma-binding protein 2 homolog 1A] |
Gene, Accession # | [JAD1B], Gene ID: 10765, NCBI: NP_001300971.1, UniProt: Q9UGL1 |
Catalog # | MBS9604061 |
Price | $240, $280 |
Order / More Info | JAD1B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |