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Antigenic Specificity | CASP4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Inflammatory caspase (PubMed: 7797510, PubMed: 23516580, PubMed: 25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed: 22246630, PubMed: 26174085, PubMed: 26173988, PubMed: 26508369, PubMed: 25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed: 24879791, PubMed: 25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed: 25121752). |
Immunogen | Immunogen: Recombinant Human Caspase-4 protein (82-226AA) |
Other Names | [Caspase-4; ICE and Ced-3 homolog 2; CASP4; ICH2] |
Gene, Accession # | [CASP4], Gene ID: 837, NCBI: NP_001216.1, UniProt: P49662 |
Catalog # | MBS7047806 |
Price | $160, $235 |
Order / More Info | CASP4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |