Edit |   |
Antigenic Specificity | CD10 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | mouse, human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD-10. Neprilysin(CD10) is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide. peptides. Neprilysin is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid. |
Immunogen | n/a |
Other Names | [neprilysin isoform a; Neprilysin; neprilysin; membrane metalloendopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10], [MME; MME; NEP; SFE; CD10; CALLA; CMT2T; SCA43; EPN; CALLA; NEP; Neutral endopeptidase; SFE] |
Gene, Accession # | [CD10], Gene ID: 4311, NCBI: NP_000893.2, UniProt: P08473 |
Catalog # | MBS857614 |
Price | $280 |
Order / More Info | CD10 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1.Malfroy B., Kuang W.-J., Seeburg P.H., Mason A.J., Schofield P.R.; Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).; FEBS Lett. 229:206-210(1988). 2.Turner AJ, Isaac RE, Coates D, et al. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function [J]. Bioessays, 2001, 23:261-269. 3.Oefner C, D'Arcy A, Hennig M, et al. Structure of Human Neutral Endopeptidase (Neprilysin) Complexed with Phosphoramidon [J]. J Mol Biol, 2000, 296:341-349. |