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Antigenic Specificity | PDGF-A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg, 0.2 mg |
Concentration | n/a |
Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PDGF is synthesized mainly by megakaryocytes. It is stored in the alpha granules of platelets from which it is released after cell activation of platelets. Platelets synthesize a mixture of the three possible isoforms (BB,AB,AA) while fibroblasts stimulated with EGF synthesize AA homodimers. PDGF receptors are expressed in fibroblasts, osteoblasts, chondroblasts, smooth muscle cells, glial cells, and endothelial cells.Two related receptors, are PDGFRalpha (CD140a) or PDGFRbeta (CD140b).In contrast to many other cytokines PDGF is not released into the circulation. PDGF binds to several plasma proteins and also to proteins of the extracellular matrix which facilitates local concentration of the factor. The factor functions as a local autocrin |
Immunogen | Source Note: Polyclonal PDGF-A antibody was produced from sera of rabbits immunized with synthetic protein containing PDGF-A antigenic determinants. |
Other Names | [Rabbit PDGF-A purified; pdgf-aa; platelet derived growth factor;; pab], [PDGFA; PDGF1; PDGF subunit A] |
Gene, Accession # | [PDGF], Gene ID: 5154, NCBI: NP_002598.4, UniProt: P04085 |
Catalog # | MBS551005 |
Price | $280, $385 |
Order / More Info | PDGF-A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |