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Antigenic Specificity | Caspase 10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Caspase 10 protein. Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.Frank C. Kischkel, J. Biol. Chem., Nov 2001; 276: 46639 - 46646.Ingo H. Engels, Mol. Cell. Biol., Apr 2005; 25: 2808 - 2818.Daniela Sciaky, J. Immunol., Apr 2000; 164: 3806.Jin Wang, PNAS, Nov 2001; 98: 13884. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human Caspase 10. |
Other Names | [ALPS2; CASP10B; FLICE2; Caspase 10 isoform a preproprotein; Caspase 10 isoform b preproprotein] |
Gene, Accession # | Gene ID: 843, NCBI: NP_001193453.1, UniProt: Q92851 |
Catalog # | MBS9401526 |
Price | $200, $255 |
Order / More Info | Caspase 10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |