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Antigenic Specificity | Phospho-Myt1 (Ser83) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Myt1 (Ser83) antibody detects endogenous levels of Myt1. Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.Subunit Structure: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.Post-translational Modifications: Autophosphorylated. Phosphoryla |
Immunogen | Immunogen: A synthesized peptide derived from human Myt1 around the phosphorylation site of Ser83. Subcellular Location: Endoplasmic Reticulum Membrane. Golgi Apparatus Membrane. Predicted Cross Reactivity: Pig, Bovine, Horse, Rabbit, Dog Similarity: Pig (92%), Bovine (80%), Horse (92%), Rabbit (83%), Dog (92%) |
Other Names | [cdc2 inhibitory kinase; DKFZp547K1610; FLJ20093; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT 1; Pkmyt1; PMYT1_HUMAN; PPP1R126; Protein kinase membrane associated tyrosine/threonine 1; Protein kinase Myt1; Protein phosphatase 1 regulatory subunit 126] |
Gene, Accession # | [Myt1], Gene ID: 9088, NCBI: NP_001245379.1, UniProt: Q99640 |
Catalog # | MBS9600697 |
Price | $240, $280 |
Order / More Info | Phospho-Myt1 (Ser83) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |