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Antigenic Specificity | ITGB7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ITGB7 antibody detects endogenous levels of total ITGB7. Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT |
Immunogen | Immunogen: A synthesized peptide derived from human ITGB7 Subcellular Location: Membrane. Tissue Specificity: Expressed in a variety of leukocyte lines. |
Other Names | [Gut homing receptor beta subunit; Integrin beta 7 subunit; Integrin beta-7; Integrin beta-P; Integrin, beta 7; ITB7; ITB7_HUMAN; Itgb7; Ly69; M290 IEL antigen] |
Gene, Accession # | [ITGB7], Gene ID: 3695, NCBI: NP_000880.1, UniProt: P26010 |
Catalog # | MBS9608498 |
Price | $240, $280 |
Order / More Info | ITGB7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |