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Antigenic Specificity | ASK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | serum |
Size | 0.05 mL |
Concentration | n/a |
Applications | Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ask1 (apoptosis signal-regulating kinase 1), a serine/threonine kinase, is a member of the MAPKKK family that constitutes the JNK and p38 (MAPK) cascades. Members of this family are activated by physiological and cytotoxic stresses and induce various stress responses including apoptosis. Specifically, Ask1-MAPK cascades have been shown to be involved in endoplasmic reticululum (ER) stress-induced apoptosis and in neuronal cell death. Studies suggest that ER stress-induced apoptosis plays critical roles in the pathogenesis in some neurodegenerative diseases including Alzheimer's, Parkinson's, polyglutamine (polyQ), amyotrophic lateral sclerosis (ALS) and Prion diseases. However, the regulation and function of Ask1 in neuronal cell death rema |
Immunogen | Immunogen Information: A synthetic peptide of ASK1 protein (amino acids 1198- 1216 CHEEQPSNQTVRRPQAVIED) was used as the immunogen for this antibody |
Other Names | [MAP3K5; ASK1; MAPKKK5; MEKK5; Apoptosis signal-regulating kinase 1; MEK kinase 5; MAPK/ERK kinase kinase 5; to ASK1; ASK1; ASK1], [MAP3K5; MAP3K5; ASK1; MEKK5; MAPKKK5; ASK1; MAPKKK5; MEKK5; ASK-1; MEK kinase 5; MEKK 5] |
Gene, Accession # | [ASK1], Gene ID: 4217, NCBI: Q99683.1, UniProt: Q99683 |
Catalog # | MBS668516 |
Price | $270 |
Order / More Info | ASK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |