Neu-Oncogen (C-erb B2) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Neu-Oncogen (C-erb B2) antibody, protein, ELISA kits.
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| Antigenic Specificity | Neu-Oncogen (C-erb B2) |
| Clone | [3B5] |
| Host Species | Mouse |
| Reactive Species | human, monkey, mouse, rat |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: 3B5 reacts equally well with the wild type as well as the mutant (oncogenic) form of the c-erbB-2/HER-2/neu protein, but preferentially recognizes the unphosphorylated form of this protein. C-erbB-2 (erythroblastosis oncogene B), also known as HER2 (Human Epidermal Growth Factor Receptor 2), or Neu, CD340 and p185 is a protein that in Humans is encoded by the ERBB2 gene. AmplifiCation or overexpression of this gene has been shown to play an important role in the pathogenesis and progression of certain aggressive types of breast cancer, as well as many other epithelial malignancies and brain tumors. In recent years it has become an important biomarker and target of therapy for disease. ERBB2 is a known proto-oncogene loCated at |
| Immunogen | Source Note: 3B5 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a synthetic peptide TAENPEYLGLDVPV corresponding to amino acid residues 1242-1255 of the C-terminus of the Human c-erbB-2/HER-2/neu protein. This sequence is identical in Rat neu protein. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS570234 |
| Price | $415 |
| Order / More Info | Neu-Oncogen (C-erb B2) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Van de Vijver, M.J., Peterse, J.L., Mooi, W.J., Wisman, P., Lomans, J., Dalesio, O. and Nusse, R. (1988). Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med. 319, 1239-45. De Potter, C.R., Van Daele, S., Van de Vijver, M.J., Pauwels, C., Maertens, G., De Boever, J., Vandekerckhove, D. and Roels, H. (1989). The expression of the neu oncogene product in breast lesions and in normal fetal and adult Human tissues. Histopathology 15, 351-62. De Potter, C.R., Quatacker, J., Maertens, G., Van Daele, S., Pauwels, C., Verhofstede, C., Eechaute, W. and Roels, H. (1989). The subcellular localization of the neu protein in Human normal and neoplastic cells. Int J Cancer 44, 969-74. Van Leeuwen, F., Van de Vijver, M.J., Lomans, J., Van Deemter, L., Jenster, G., Akiyama, T., Yamamoto, T. and Nusse, R. (1990). Mutation of the Human neu protein facilitates down-modulation by monoclonal antibodies. Oncogene. 5, 497-503. Singleton, T.P., Niehans, G.A., Gu, F., Litz, C.E., Hagen, K., Qiu, Q., Kiang, D.T. and Strickler, J.G. (1992). Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry. Hum Pathol. 23, 1141-50. Schwechheimer, K., Laufle, R.M., Schmahl, W., Knodlseder, M., Fischer, H. and Hofler, H. (1994). Expression of neu/c-erbB-2 in Human brain tumors. Hum Pathol. 25, 772-80. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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