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Antigenic Specificity | RGS14 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: RGS14 antibody detects endogenous levels of total RGS14. Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nucleus. Nucleus > PML Body. Cytoplasm. Membrane. Cell Membrane. Cytoplasm > Cytoskeleton > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Spindle Pole. Cell Projection > Dendrite. Cell Projection > Dendritic Spine. Cell Junction > Synapse > Postsynaptic Cell Membrane > Postsynaptic Density. Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastra |
Other Names | [Highly similar to rap1/rap2 interacting protein; OTTHUMP00000223586; OTTHUMP00000223587; Regulation of G protein signaling 14; Regulator of G protein signaling 14; Regulator of G protein signalling 14; Regulator of G-protein signaling 14; RGS 14; RGS14; RGS14_HUMAN] |
Gene, Accession # | [RGS14], Gene ID: 10636, NCBI: NP_006471.2, UniProt: O43566 |
Catalog # | MBS9605870 |
Price | $240, $280 |
Order / More Info | RGS14 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |