BRCA2 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | BRCA2 |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; |
| Immunogen | n/a |
| Other Names | [Purified Mouse (Mab); Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein; BRCA2; FACD; FANCD1] |
| Gene, Accession # | [BRCA2], Gene ID: 675, NCBI: NP_000050.2, UniProt: P51587 |
| Catalog # | MBS9216853 |
| Price | $165, $370 |
| Order / More Info | BRCA2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wooster R.,et al.Nature 378:789-792(1995). Tavtigian S.V.,et al.Nat. Genet. 12:333-337(1996). Dunham A.,et al.Nature 428:522-528(2004). Ozcelik H.,et al.Nat. Genet. 16:17-18(1997). Hussain S.,et al.Hum. Mol. Genet. 13:1241-1248(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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