Bcr Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Bcr |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Bcr. The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene (1). The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region may be involved in a GTPase activating function for the small GTP-binding protein Rac (2,3). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator (4). The Bcr-Abl fusion results in production of a constitutively active tyrosine kinase, |
| Immunogen | Immunogen: A synthetic -peptide of human Bcr |
| Other Names | [BCR; Bcr; Bcr; BCR; ALL; BCR1; CML; D22S11; D22S662; FLJ16453; PHL], [BCR; BCR; ALL; CML; PHL; BCR1; D22S11; D22S662; BCR1; D22S11] |
| Gene, Accession # | Gene ID: 613, NCBI: NP_004318.3, UniProt: P11274 |
| Catalog # | MBS125290 |
| Price | $200, $275, $430 |
| Order / More Info | Bcr Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Groffen, J. et al. (1984) Cell 36, 93-99. 2. Maru, Y. et al. (1991) Cell 67, 459-468. 3. Che, W. et al. (2001) Circulation 104, 1399-1406. 4. Abe, J. I. et al. (2001) Ann. N.Y. Acad. Sci. 947, 341-343. 5. Voncken, J. W. et al. (1995) Cell 80, 719-728. 6. He, Y. et al. (2002) Blood 99, 2957-2968. 7. Sattler, M. et al. (2002) Cancer Cell 1, 479-492. 8. Warmuth, M. et al. (1995) J. Biol. Chem. 272, 33260-33270. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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