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Antigenic Specificity | SATB1 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or |
Immunogen | Immunogen: A synthesized peptide derived from human SATB1. Subcellular Localization: Nucleus matrix. Nucleus, PML body. Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs). Tissue Specificity: Expressed predominantly in thymus. |
Other Names | [DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1; SATB1], [SATB1; SATB1] |
Gene, Accession # | [SATB1], Gene ID: 6304, NCBI: NP_001124482.1, UniProt: Q01826 |
Catalog # | MBS179626 |
Price | $160, $340, $340 |
Order / More Info | SATB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |