c-Abl (Phospho-Tyr245) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | c-Abl (Phospho-Tyr245) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous level of c-Abl only when phosphorylated at tyrosine 245. Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and |
| Immunogen | Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phosphospecific antibodies were removed by chromatogramphy using non-phosphopeptide. Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 245 (T-V-Y(p)-G-V) derived from Human c-Abl. |
| Other Names | [p150; c-ABL; EC 2.7.10.2] |
| Gene, Accession # | [c-Abl], Gene ID: 25, NCBI: NP_005148.2, UniProt: P00519 |
| Catalog # | MBS9408149 |
| Price | $200, $255 |
| Order / More Info | c-Abl (Phospho-Tyr245) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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