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Antigenic Specificity | SMYD2 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous levels of SMYD2 and does not cross-react with related proteins. UniPort Summary Function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 ?Lys-4? (H3K4me) and dimethylates histone H3 ?Lys-36? (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates ?Lys-370? of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates ?Lys-860? of RB1/RB. Entrez Summary: SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] |
Immunogen | Immunogen: Purified recombinant human SMYD2 protein fragments expressed in E Coli. Cellular Localization: Cytoplasm Cytosol; Nucleus |
Other Names | [HSKM-B; Histone methyltransferase SMYD2; EC=2.1.1.43; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2], [KMT3C; HSKM-B; ZMYND14] |
Gene, Accession # | [SMYD2], Gene ID: 56950, NCBI: NP_064582.2, UniProt: Q9NRG4 |
Catalog # | MBS857789 |
Price | $300 |
Order / More Info | SMYD2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |