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Antigenic Specificity | IL3RA/CD123 (Acute Myeloid Leukemia Marker) |
Clone | [IL3RA/1531] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG2b, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y. |
Immunogen | Immunogen: Recombinant fragment of human IL3RA protein (around aa26-171) (exact sequence is proprietary) Positive Control: THP-1, RPMI-8226 or HDLM-2 Cells. Tonsil, Lymph Node or Stomach |
Other Names | [CD123; hIL3Ra; IL-3R-alpha; IL-3RA; IL3RAX; IL3RAY; IL3RX; IL3RY; Interleukin-3 Receptor, alpha; Interleukin3 receptor; Interleukin3 receptor, Y-chromosomal] |
Gene, Accession # | [IL3RA], Gene ID: 3563, NCBI: NP_001254642.1, UniProt: P26951 |
Catalog # | MBS4380603 |
Price | $190, $340, $340 |
Order / More Info | IL3RA/CD123 (Acute Myeloid Leukemia Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Rollins-Raval M, Pillai R, Warita K, Mitsuhashi-Warita T, Mehta R, Boyiadzis M, Djokic M, Kant JA, Roth CG.CD123 immunohistochemical expression in acute myeloid leukemia is associated with underlying FLT3-ITD and NPM1 mutations.Appl Immunohistochem Mol Morphol. 2013 May; 21(3):212-7 |