Phospho-Dnmt1 (S714) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-Dnmt1 (S714) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.335 |
| Applications | Dot Blot (DB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Dnmt1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S714 of human Dnmt1. Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dn |
| Immunogen | n/a |
| Other Names | [DNA (cytosine-5)-methyltransferase 1; Dnmt1; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; MHsaI; MCMT; DNMT1; AIM; CXXC9; DNMT] |
| Gene, Accession # | [DNMT1], Gene ID: 1786, NCBI: NP_001124295.1, UniProt: P26358 |
| Catalog # | MBS9210453 |
| Price | $165, $370 |
| Order / More Info | Phospho-Dnmt1 (S714) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Peterson, E.J., et al., Cancer Res. 63(20):6579-6582 (2003). Leu, Y.W., et al., Cancer Res. 63(19):6110-6115 (2003). Saito, Y., et al., Int. J. Cancer 105(4):527-532 (2003). Siedlecki, P., et al., Biochem. Biophys. Res. Commun. 306(2):558-563 (2003). Macaluso, M., et al., Oncogene 22(23):3511-3517 (2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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